1) 1차년도(2011.07.01~2012.06.30)

일련
번호
논문명 연구자 발표일과제번호 발표지 논문 수준 사사기관
국내 국외 SCI
1 Alpinia katsumadai Suppresses Migration and 12-O-tetradecanoylphorbol-13-acetate-induced Invasion of HT-1080 cells through suppression of transglutaminase-2, matrix metalloproteinase-2, and matrix metaalloproteinase-9 expression 박미경,
이창훈
11.12.31 Cancer
Prevention
Research
O GRRC
NRF
NRF
2 Mangosteen Xanthones, α-and γ-mangosteen, inhibit allergic mediators in bone marrow-derived mast cells Chae HS,
Oh SR,
Lee HK,
Joo SH,
Chin YW
12.02.02
accepted
Food
Chemistry
O GRRC
3 Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors 하연,
최현경,
이경
12.03.01 Eur J Med
Chem
O GRRC
NRF
KRIBB
4 Effects of cysteine on the pharmacokinetics of paclitaxel in rats 한승연,
윤인수,
진영원,
조일환,
이명걸,
최영희
12.03.09 Arch Pharm Res O
(SCIE)
GRRC
5 Regulation of Nrf2-mediated phase Ⅱ detoxification and anti-oxidant genes 금영삼 12.03.31 Biomolecules &
Therapeutics
O GRRC
6 Improved oral bioavailability of alendronate via the mucoadhesive liposomal delivery system. Han HK,
Shin HJ,
Ha DH
12.04.05
accepted
Eur. J.
Pharm. Sci.
O GRRC
NRF
7 Enhanced systemic exposure of fexofenadine via the intranasal administration of chitosan-coated liposome. Qiang F,
Shin HJ,
Lee BJ,
Han Hk
12.04.05
accepted
Int. J.
Pharm.
O GRRC
복지부
8 Cytotoxic terpenes from the stems of DIptero carpue obtueifoliue collected in Cambodia Piseth k,
Ok Kwon,
HH Song,
SR Oh,
KS Ahn,
Hk Lee,
YW Chin
12.04.10
accepted
Chem Pharm
Bull
O GRRC
KRIBB
교과부
9 Fluorocyclopentenyl-cytosine with broad spectrum and potent antitumor activity 최원준,
정화진,
기리쉬,
알렉스,
조룡현,
이혁우,
아그샤타,
마직,
김혜옥,
김진희,
이영복,
안창호,
이상국,
정낙신
12.04.23 Journal of
Medicinal
Chemistry
O GRRC
WCU
Seoul
NRF
10 Pharmacokinetic interaction between metoprolol and SP-8203 in rats: competitive inhibition for the metabolism of metoprolol by SP-8203 via hepatic CYP2D subfamily 이유경,
한승연,
진영원,
최영희
12.05.09 Xenobiltica O GRRC
11 Transglutaminase-2 is involved in all-trans retinoic acid-induced invasion and matrix metalloproteinases expression of SH-SY5Y neuroblastoma cells via NF-B pathway 이혜자,
박미경,
배현철,
윤희정,
김수열,
이창훈
12.05.31 Biomolecules &
Therapeutics
O
(SCIE)
GRRC
NRF
NRF
NRF
12 DIscrimination of JNK3 bound small molecules by saturation transfer difference NMR experiments 임종수,
안희철
12.06.08
accepted
J. Kor.
Magnet. Res.
Soc
O GRRC
년 계 2 10

2) 2차년도(2011.07.01~2012.06.30)

일련
번호
논문명 연구자 발표일과제번호 발표지 논문 수준 사사기관
국내 국외 SCI
1 Anti-inflammatory and anti-allergic effect of Agaricus blazei extract in bone marrow-derived mast cells Song H-H,
Chae H-S,
Oh S-R,
Lee H-K,
Chin Y-W
2012.08.29
2012-B02
Am. J. Chin. Med. GRRC
2 Repeated dosing of piperine induced gene expression of P-glycoprotein via stimulated pregnane-X-receptor activity and altered pharmacokinetics of diltiazem in rats Qiang F,
Kang KW,
Han HK
2012.09.18
2012-B03
Biopharm. Drug Dispos. GRRC,
NRF
3 Pharmacokinetic interaction between metoprolol and SP-8203 in rats: competitive inhibition for the metabolism of metoprolol by SP-8203 via hepatic CYP2D subfamily Han SY,
Yoon I,
Chin YW,
Cho IW,
Lee MG,
Choi YH.
2012.10.01
2012-B03
Xenobiotica GRRC
4 Roles of phosphoinositides and phosphoinositides kinases in hepatitis C virus RNA replication Choongho Lee 2012.10.01
2012-A01
Arch. Pharm. Res. GRRC
5 A facile synthetic route to diazepinone derivatives via ring closing metathesis and its application for human cytidine deaminase inhibitors Minkyoung Kim, Kondaji Gajulapati, Chorong Kim, Hwa Young Jung, Jail Goo, Kyeong Lee, Navneet Kaur, Hyo Jin Kang, Sang J. Chung, Yongseok Choi 2012.10.08
2012-B02
Chem. Commun. NRF,
Korea Univ.,
GRRC
6 Discovery of a novel series of benzimidazole derivatives as diacylglycerol acyltransferase inhibitors Kyeong Lee,
Ja-Il Goo,
Hwa Young Jung,
Minkyoung Kim,
Shanthaveerappa K. Boovanahalli,
Hye Ran Park,
Mun-Ock Kim,
Dong-Hyun Kim,
Hyun Sun Lee,
Yongseok Choi
2012.10.17
2012-B02
Bioorg. Med. Chem. Lett. KRIBB,
NRF,
GRRC
7 Mangosteen xanthones mitigate ovalbumin-induced airway inflammation in a mouse model of asthma Jang H-Y,
Kwon O-K,
Oh S-R,
Lee H-K,
Ahn K-s,
Chin YW
2012.11.01
2012-B02
Food Chem. Toxicol. GRRC,
KRIBB
8 Development of chemical inhibitors of the SARS coronavirus: viral helicase as a potential target Young-Sam Keuma,
Yong-Joo Jeong
2012.11.15
2012-A01
Biochem. Pharmacol. NRF,
GRRC
9 Biocompatible dispersion methods for carbon black Kim H,
Park K,
Lee MY
2012.12.30
2012-B01
Toxicol. Res. GRRC,
KOSHA
10 A new approach for pharmacokinetic studies of natural products: measurement of isoliquiritigenin levels in mice plasma, urine and feces using modified automated dosing/blood sampling system Seung Yon Han,
Young-Won Chin,
Young Hee Choi
2013.01.21
2012-B03
Biomed. Chromatogr. NRF,
GRRC
11 Finasteride increases the expression of hemoxygenase-1 (HO-1) and NF-E2-related factor-2 (Nrf2) proteins in PC-3 cells: implication of finasteride-mediated high-grade prostate tumor occurrence Do-Kyung Yun,
June Lee,
Young-Sam Keum
2013.01.31
2012-A01
Biomol. Ther. GRRC
12 Menadione serves as a substrate for P-glycoprotein: implication in chemosensitizing activity Seok-Jeong Oh,
Hyo-Kyung Han,
Keon-Wook Kang,
Young-Joo Lee,
Moo-Yeol Lee
2013.02.23
2012-B012012-B03
Arch. Pharm. Res. GRRC
(1-1, 2-2 세부과제 공동사사)
13 Interaction of hepatitis C virus core protein with Janus kinase is required for efficient production of infectious viruses Choongho Lee 2013.03.31
2012-A01
Biomol. Ther. GRRC
14 Feasibility of simultaneous measurement of cytosolic calcium and hydrogen peroxide in vascular smooth muscle cells Kyung-Hwa Chang,
Jung-Min Park,
Moo-Yeol Lee
2013.05.21
accepted
2012-B01
BMB Rep. GRRC,
NRF
15 Transglutaminase-2 is involved in expression of osteoprotegerin in MG-63 osteosarcoma cells Hye Ja Lee,
Chang Hoon Lee
2013.5.22
accepted
2012-B01
Biomol. Ther. GRRC
16 Role of chemokine CCL2 and its receptor CCR2 in neurodegenerative diseases Shambhunath Bose,
Jungsook Cho
2013.05.20
accepted
2012-B01
Arch. Pharm. Res. GRRC
년 계 1 15
합 계 3 25

 

3) 3차년도(2013.07.01∼2014.06.30)

일련
번호
논문명 연구자 발표일과제번호 발표지 논문 수준 사사기관
국내 국외 SCI
1 Effects of Korean red ginseng extract on acute renal failure induced by gentamicin and pharmacokinetic changes by metformin in rats Lee YK,
Chin YW,
Choi YH
2013.09.31
2013-B03
Food Chem. Toxicol. NRF,GRRC
2 Daclatasvir: potential role in hepatitis C Lee C 2013.10.15
2013-A01
Drug Des, Dev. Ther. GRRC,
NRF
3 3-aminopropyl functionalized magnesium phyllosilicate as an organoclay based drug carrier for improving the bioavailability of flurbiprofen. Yang L,
Cho SK,
Shin HJ,
Han HK
2013.10.30
2013-B03
Int, J. Nanomedicine NRF1,
NRF2,
GRRC
4 Pharmacokinetics of Isoliquiritigenin and ItsMetabolites in Rats: Low Bioavailability Is PrimarilyDue to the Hepatic and Intestinal Metabolism Lee YK,
Chin YW,
Bae JK,
Seo JS,
Choi YH
2013.11.25
2013-B03
Planta Med. NRF,
GRRC
5 Absorption, tissue distribution, tissue metabolism and safetyof a-mangostin in mangosteen extract using mouse models Young Hee Choi,
Seung Yon Han,
You-Jin Kim,
Young-Mi Kim,
Young-Won Chin
2014.01.25
2013-B03
Food Chem. Toxicol. NRF,
GRRC
6 Chemical genetics-based discovery of indole derivatives as HCV NS5B polymerase inhibitors Guanghai Jin,
Sungjin Lee,
Moonju Choi,
Seohyun Son,
Geon-Woo Kim,
Jong-Won Oh,
Choongho Lee,
Kyeong Lee
2014.01.31
2013-A01
2013-B02
Eur. J. Med.
Chem.
GRRC,
NRF
7 Enhancement of Platelet Aggregation by Ursolic Acid and OleanolicAcid Kim M,
Han CH,Lee MY
Accepted
2014.03.24
2013-B01
Biomol. Ther. GRRC
8 12-O-Tetradecanoylphorbol-13-Acetate Induces Keratin 8Phosphorylation and Reorganization via Expression of Transglutaminase-2 Lee EJ,
Park MK,
Kim HJ,
Kang JH,
Kim YR,
Kang GJ,
Byun HJ,
Lee CH
2014.03.31
2013-B01
Biomol. Ther. GRRC,
Korea
Healthcare
Technology
R&D
project,
MOHW
9 Involvement of Transglutaminase-2 in α-MSH-InducedMelanogenesis in SK-MEL-2 Human Melanoma Cells Kim HJ,
Lee HJ,
Park MK,
Gang J,
Byun HJ,
Par JH,
Kim MK,
Kim SY,
Lee CH
Accepted
2014.05.07
2013-B01
Biomol. Ther. GRRC
10 Improved pH-dependent drug release and oral exposure of telmisartan, a poorly soluble drug through the formation of drug-aminoclay complex Yang L,
Shao Y,
Han HK
Accepted
2014.05.09
2013-B03
Int. J. Pharm. NRF,
MOHW,
GRRC
11 Therapeutic Strategies for Metabolic Diseases: Small Molecule Diacylglycerol Acyltrasferase (DGAT) Inhibitors Naik R,
Obiang-Obounou BW,
Kim M,
Choi,
Lee HS,
Lee K
Accepted
2014.05.14
2013-B02
Chem..Med..
Chem
GRRC,
NRF
12 Korean Red Ginseng Extract Exhibits Neuroprotective Effects throughInhibition of Apoptotic Cell Death Kim S,
Lee Y,
Cho J
2014.06.01
2013-B01
Biol. Pharm.
Bull.
GRRC,
Korean
Society of
Ginseng
13 The Heterochromatin-1 Phosphorylation Contributes to TPA-induced AP-1 Expression Choi WJ Accepted
2014.05.26
2013-B02
Biomol. Ther. GRRC,
NRF
14 Mangosteen xanthones suppress hepatitis C virus genome replication Choi M,
Kim YM,
Lee S,
Chin YW,
Lee C
Accepted
2014.06.16
2013-A0
12013-B02
Biochem. Biophys.
Res. Commun.
GRRC
년 계 14
합 계 3 39

4) 4차년도(2014.07.01~2015.06.30)

일련
번호
논문명 연구자 발표일과제번호 발표지 논문 수준 사사기관
국내 국외 SCI
1 Molecular and chemical regulation of the keap1-nrf2
signaling pathway
Keum YS,
Choi BJ
2014.07.10
2014-B02
Molecules GRRC,
KICOX
2 Pharmacokinetics, tissue distribution, and tentative metabolite identification of sauchinone in mice by microsampling and HPLCMS/MS methods Kim YJ,
Han SY,
Seo JS,
Chin YW,
Choi YH
2015.02.10
2014-B01
Biol.
Pharm.
Bull.
GRRC
3 Identification of a new selective chemical inhibitor of mutant isocitrate dehydrogenase-1 Kim HJ,
Choi BJi,
Keum YS
2015.03.31
2014-B02
J.Cancer Prevent. 0 GRRC
4 In vivo gastroprotective effect along with pharmacokinetics, tissue distribution and metabolism of isoliquiritigenin in mice Choi YH,
Kim YJ,
Chae HS,
Chin YW
2015.04.15
2014-B01
Planta Med. GRRC
5 Antiplatelet effect of a newly developed AMP-activated protein kinase activator YLF-466D Liu Y,
Park JM,
Oh SJ,
Chang KH,
Lee MY
2015.04.22
2014-B03
Eur.
J.Pharmacol
GRRC
6 Neuroprotective and antioxidant effects of novel
benzofuran-2-carboxamide derivatives
Cho J,
Park C, Lee Y, Kim S, Bose S,
Choi M,
Kumar AS, Jung JK, Lee H
2015.05.01
2014-B01
Biomol& Ther. GRRC
NRF
7 Immortalization of primary keratinocytes and its application to skin research Choi M,
Lee C
Accepted
2015.05.06
2014-A01
Biomol& Ther. GRRC
보건산업진흥원
8 Methods for treating interleukin-6 related diseases Chin YW Accepted
2015.05.22
2014-B03
Expert Opin.Ther.Pat GRRC
9 Recombinant kinase production and fragment screening by NMR spectroscopy Ahn HC,
Han B
Accepted
2015.04.27
2014-B02
Methods in Molecular biology GRRC
10 Antimicrobial activity of doubly-stapled alanine/lysine-based helices Dinh TTT,
Kim DH,
Luonga HX,
Lee BJ,
Kim YW
Submitted
2015.04.30
2014-B02
Bioor. Med. Chem. Lett. GRRC
NRF
11 N-capping effect of stapled heptapeptides on antimicrobial activity Dinh TTT,
Kim DH,
Nguyen TQ,
Lee BJ,
Kim YW
Submitted
2015.05.28
2014-B02
Bull. Kor. Chem. Soc. GRRC
NRF
12 Novel lignans with IL-6 production inhibitory activity from larrea nitidia Choi WJ Submitted
2015.06.00
2014-A01
Bioor. Med. Chem. Lett. GRRC, MEST
년 계 1 11

 

5) 5차년도(2015.07.01~2016.06.30)

일련
번호
논문명 연구자 발표일과제번호 발표지 논문 수준 사사기관
국내 국외 SCI
1 Dose-Independent ADME Properties and
Tentative Identification of Metabolites of α-
Mangostin from Garcinia mangostana in
Mice by Automated Microsampling and
UPLC-MS/MS Methods
Seung Yon Han, Byoung Hoon You, Yu Chul Kim,Young-Won Chin, Young Hee Choi 15.06.20
2015-B01
PLOS ONE O GRRC
NRF
2 α‑Mangostin Regulates Hepatic Steatosis and Obesity through SirT1-AMPK and PPARγ Pathways in High-Fat Diet-Induced Obese Mice Young Hee Choi, Jin Kyung Bae, Hee-Sung Chae, Young-Mi Kim, Yim Sreymom, Ling Han,
Ha Young Jang, Young-Won Chin
15.11.15
2015-B03
J.Agric. Food
Chem.
O GRRC
NRF
3 Antioxidant and anti-inflammatory
activities of N-((3,4-dihydro-
2H-benzo[h]chromene-2-yl)methyl)-4-
methoxyaniline in LPS-induced BV2
microglial cells
Moniruzzaman,
Gyeongjun Lee,
Shambhunath Bose,Minho Choi,Jae-Kyung Jung,
Heesoon Lee,Jungsook Cho
15.12.01
2015-B01
Biol. Pharm. Bull. O GRRC
NRF
4 Antimicrobial and Hemolytic Activity of Stapled Heptapeptide Dimers Young-Woo Kim
Huy X. Luong, Do-Hee Kim, Bong-Jin Lee
submitted
yy.mm.dd
2015-B02
Bull.
Kor.
Chem.
Soc.
O GRRC
NRF
5 Identification of a resveratrol tetramer as a potent inhibitor of hepatitis C virus helicase Lee S, Yoon KD, Lee M, Cho Y, Choi G, Jang H4, Kim B, Jung DH6, Oh JG, Kim GW, Oh JW, Jeong YJ, Kwon HJ, Bae SK, Min DH, Windisch MP, Heo TH, Lee C 16.01.01
2015-A01
Br. J. Pharmacol. O GRRC
NRF
6 Isoliquiritigenin ameliorates dextran sulfate sodium-induced colitis
through the inhibition of MAPK pathway
Young Hee Choi, Jin-Kyung Bae, Hee-Sung Chae, Young Ok Choi, Piseth Nhoek,
Jong-Sun Choi, Young-Won Chin
16.01.07
2015-B01
Int. Immunopharmacol. O GRRC
KHIDI
7 The ethylacetate fraction from Physalis alkekengi inhibits LPS-induced pro-inflammatory mediators in BV2 cells and inflammatory pain in mice Moniruzzaman, ShambhunathBose, Young-MiKim, Young-WonChin,
Jungsook Cho
16.04.02
2015-B01
J.
Ethnopharmacol.
O GRRC
8 Mangosteen Extract Attenuates the Metabolic Disorders
of High-Fat-Fed Mice by Activating AMPK
Hee-Sung Chae, Young-Mi Kim, Jin-Kyung Bae, Sochivak Sorchhann, Sreymom Yim,
Ling Han, Jin Hyub Paik, Young Hee Choi, Young-Won Chin
16.02.01
2015-B01
2015–B03
J.MED. FOOD O GRRC
NRF
9 Xanthones with pancreatic lipase inhibitory activity from the
pericarps of Garcinia mangostana L. (Guttiferae)
Hee-Sung Chae, Young-Mi Kim, Jin-Kyung Bae, Sochivak Sorchhann, Sreymom Yim,
Ling Han, Jin Hyub Paik, Young Hee Choi, Young-Won Chin
accepted
2015-B03
Eur. J.Lipid Science Technol. O GRRC
NRF
10 Maackiapterocarpan B from Sophora tonkinensis Suppresses
Inflammatory Mediators via Nuclear Factor-κB and Mitogen-Activated
Protein Kinase Pathways
Hee-Sung Chae, Hunseung Yoo, Young Hee Choi, Won Jun Choi, Young-Won Chin 16.05.01
2015-A01
Biol. Pharm. Bull. O GRRC
NRF
NHIDI
iPET
11 Crystal structures of apo- and AMP-bound human c-Jun N-terminal kinase3 Yumi Eo, Byeong Gu Han, Myungbo Shim, Jong Soo Lim, Thuy Nguyen Thi Phuong, Phuong Pham Hoa, Hee Chul Ahn Accepted
16.05.23
2015-B02
Bull.Kor. Chem.Soc. O GRRC
NRF
12 Acetonitrile extract of Salvia miltiorrhiza Radix exhibits the growth-inhibitory effects on prostate cancer through the induction of cell-cycle arrest and apoptosis June Lee, Bu-Young Choi, Young-Sam Keum In press
16.03.01
2015-B02
Oncol. Lett. 0 GRRC
13 Treatment of α-mangostin Sensitizes 5-fluorouracil-resistant SNUC5 Colon Cancer Cells to Apoptosis June Lee, Jong-Su Kang, Bu-Young Choi, Young-Sam Keum In press
16.04.07
2015-B02
Biomol. Ther. 0 GRRC
년 계 13
합 계 4 63