연구논문
1차년도(2011.07.01~2012.06.30)
| 일련 번호 |
논문명 | 연구자 | 발표일과제번호 | 발표지 | 논문 수준 | 사사기관 | ||
|---|---|---|---|---|---|---|---|---|
| 국내 | 국외 | SCI | ||||||
| 1 | Alpinia katsumadai Suppresses Migration and 12-O-tetradecanoylphorbol-13-acetate-induced Invasion of HT-1080 cells through suppression of transglutaminase-2, matrix metalloproteinase-2, and matrix metaalloproteinase-9 expression | 박미경, 이창훈 |
11.12.31 | Cancer Prevention Research |
O | GRRC NRF NRF |
||
| 2 | Mangosteen Xanthones, α-and γ-mangosteen, inhibit allergic mediators in bone marrow-derived mast cells | Chae HS, Oh SR, Lee HK, Joo SH, Chin YW |
12.02.02 accepted |
Food Chemistry |
O | GRRC | ||
| 3 | Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors | 하연, 최현경, 이경 |
12.03.01 | Eur J Med Chem |
O | GRRC NRF KRIBB |
||
| 4 | Effects of cysteine on the pharmacokinetics of paclitaxel in rats | 한승연, 윤인수, 진영원, 조일환, 이명걸, 최영희 |
12.03.09 | Arch Pharm Res | O (SCIE) |
GRRC | ||
| 5 | Regulation of Nrf2-mediated phase Ⅱ detoxification and anti-oxidant genes | 금영삼 | 12.03.31 | Biomolecules & Therapeutics |
O | GRRC | ||
| 6 | Improved oral bioavailability of alendronate via the mucoadhesive liposomal delivery system. | Han HK, Shin HJ, Ha DH |
12.04.05 accepted |
Eur. J. Pharm. Sci. |
O | GRRC NRF |
||
| 7 | Enhanced systemic exposure of fexofenadine via the intranasal administration of chitosan-coated liposome. | Qiang F, Shin HJ, Lee BJ, Han Hk |
12.04.05 accepted |
Int. J. Pharm. |
O | GRRC 복지부 |
||
| 8 | Cytotoxic terpenes from the stems of DIptero carpue obtueifoliue collected in Cambodia | Piseth k, Ok Kwon, HH Song, SR Oh, KS Ahn, Hk Lee, YW Chin |
12.04.10 accepted |
Chem Pharm Bull |
O | GRRC KRIBB 교과부 |
||
| 9 | Fluorocyclopentenyl-cytosine with broad spectrum and potent antitumor activity | 최원준, 정화진, 기리쉬, 알렉스, 조룡현, 이혁우, 아그샤타, 마직, 김혜옥, 김진희, 이영복, 안창호, 이상국, 정낙신 |
12.04.23 | Journal of Medicinal Chemistry |
O | GRRC WCU Seoul NRF |
||
| 10 | Pharmacokinetic interaction between metoprolol and SP-8203 in rats: competitive inhibition for the metabolism of metoprolol by SP-8203 via hepatic CYP2D subfamily | 이유경, 한승연, 진영원, 최영희 |
12.05.09 | Xenobiltica | O | GRRC | ||
| 11 | Transglutaminase-2 is involved in all-trans retinoic acid-induced invasion and matrix metalloproteinases expression of SH-SY5Y neuroblastoma cells via NF-B pathway | 이혜자, 박미경, 배현철, 윤희정, 김수열, 이창훈 |
12.05.31 | Biomolecules & Therapeutics |
O (SCIE) |
GRRC NRF NRF NRF |
||
| 12 | DIscrimination of JNK3 bound small molecules by saturation transfer difference NMR experiments | 임종수, 안희철 |
12.06.08 accepted |
J. Kor. Magnet. Res. Soc |
O | GRRC | ||
| 년 계 | 2 | 10 | ||||||
2차년도(2011.07.01~2012.06.30)
| 일련 번호 |
논문명 | 연구자 | 발표일과제번호 | 발표지 | 논문 수준 | 사사기관 | ||
|---|---|---|---|---|---|---|---|---|
| 국내 | 국외 | SCI | ||||||
| 1 | Anti-inflammatory and anti-allergic effect of Agaricus blazei extract in bone marrow-derived mast cells | Song H-H, Chae H-S, Oh S-R, Lee H-K, Chin Y-W |
2012.08.29 2012-B02 |
Am. J. Chin. Med. | ○ | GRRC | ||
| 2 | Repeated dosing of piperine induced gene expression of P-glycoprotein via stimulated pregnane-X-receptor activity and altered pharmacokinetics of diltiazem in rats | Qiang F, Kang KW, Han HK |
2012.09.18 2012-B03 |
Biopharm. Drug Dispos. | ○ | GRRC, NRF |
||
| 3 | Pharmacokinetic interaction between metoprolol and SP-8203 in rats: competitive inhibition for the metabolism of metoprolol by SP-8203 via hepatic CYP2D subfamily | Han SY, Yoon I, Chin YW, Cho IW, Lee MG, Choi YH. |
2012.10.01 2012-B03 |
Xenobiotica | ○ | GRRC | ||
| 4 | Roles of phosphoinositides and phosphoinositides kinases in hepatitis C virus RNA replication | Choongho Lee | 2012.10.01 2012-A01 |
Arch. Pharm. Res. | ○ | GRRC | ||
| 5 | A facile synthetic route to diazepinone derivatives via ring closing metathesis and its application for human cytidine deaminase inhibitors | Minkyoung Kim, Kondaji Gajulapati, Chorong Kim, Hwa Young Jung, Jail Goo, Kyeong Lee, Navneet Kaur, Hyo Jin Kang, Sang J. Chung, Yongseok Choi | 2012.10.08 2012-B02 |
Chem. Commun. | ○ | NRF, Korea Univ., GRRC |
||
| 6 | Discovery of a novel series of benzimidazole derivatives as diacylglycerol acyltransferase inhibitors | Kyeong Lee, Ja-Il Goo, Hwa Young Jung, Minkyoung Kim, Shanthaveerappa K. Boovanahalli, Hye Ran Park, Mun-Ock Kim, Dong-Hyun Kim, Hyun Sun Lee, Yongseok Choi |
2012.10.17 2012-B02 |
Bioorg. Med. Chem. Lett. | ○ | KRIBB, NRF, GRRC |
||
| 7 | Mangosteen xanthones mitigate ovalbumin-induced airway inflammation in a mouse model of asthma | Jang H-Y, Kwon O-K, Oh S-R, Lee H-K, Ahn K-s, Chin YW |
2012.11.01 2012-B02 |
Food Chem. Toxicol. | ○ | GRRC, KRIBB |
||
| 8 | Development of chemical inhibitors of the SARS coronavirus: viral helicase as a potential target | Young-Sam Keuma, Yong-Joo Jeong |
2012.11.15 2012-A01 |
Biochem. Pharmacol. | ○ | NRF, GRRC |
||
| 9 | Biocompatible dispersion methods for carbon black | Kim H, Park K, Lee MY |
2012.12.30 2012-B01 |
Toxicol. Res. | ○ | GRRC, KOSHA |
||
| 10 | A new approach for pharmacokinetic studies of natural products: measurement of isoliquiritigenin levels in mice plasma, urine and feces using modified automated dosing/blood sampling system | Seung Yon Han, Young-Won Chin, Young Hee Choi |
2013.01.21 2012-B03 |
Biomed. Chromatogr. | ○ | NRF, GRRC |
||
| 11 | Finasteride increases the expression of hemoxygenase-1 (HO-1) and NF-E2-related factor-2 (Nrf2) proteins in PC-3 cells: implication of finasteride-mediated high-grade prostate tumor occurrence | Do-Kyung Yun, June Lee, Young-Sam Keum |
2013.01.31 2012-A01 |
Biomol. Ther. | ○ | GRRC | ||
| 12 | Menadione serves as a substrate for P-glycoprotein: implication in chemosensitizing activity | Seok-Jeong Oh, Hyo-Kyung Han, Keon-Wook Kang, Young-Joo Lee, Moo-Yeol Lee |
2013.02.23 2012-B012012-B03 |
Arch. Pharm. Res. | ○ | GRRC (1-1, 2-2 세부과제 공동사사) |
||
| 13 | Interaction of hepatitis C virus core protein with Janus kinase is required for efficient production of infectious viruses | Choongho Lee | 2013.03.31 2012-A01 |
Biomol. Ther. | ○ | GRRC | ||
| 14 | Feasibility of simultaneous measurement of cytosolic calcium and hydrogen peroxide in vascular smooth muscle cells | Kyung-Hwa Chang, Jung-Min Park, Moo-Yeol Lee |
2013.05.21 accepted 2012-B01 |
BMB Rep. | ○ | GRRC, NRF |
||
| 15 | Transglutaminase-2 is involved in expression of osteoprotegerin in MG-63 osteosarcoma cells | Hye Ja Lee, Chang Hoon Lee |
2013.5.22 accepted 2012-B01 |
Biomol. Ther. | ○ | GRRC | ||
| 16 | Role of chemokine CCL2 and its receptor CCR2 in neurodegenerative diseases | Shambhunath Bose, Jungsook Cho |
2013.05.20 accepted 2012-B01 |
Arch. Pharm. Res. | ○ | GRRC | ||
| 년 계 | 1 | 15 | ||||||
| 합 계 | 3 | 25 | ||||||
3차년도(2013.07.01∼2014.06.30)
| 일련 번호 |
논문명 | 연구자 | 발표일과제번호 | 발표지 | 논문 수준 | 사사기관 | ||
|---|---|---|---|---|---|---|---|---|
| 국내 | 국외 | SCI | ||||||
| 1 | Effects of Korean red ginseng extract on acute renal failure induced by gentamicin and pharmacokinetic changes by metformin in rats | Lee YK, Chin YW, Choi YH |
2013.09.31 2013-B03 |
Food Chem. Toxicol. | ○ | NRF,GRRC | ||
| 2 | Daclatasvir: potential role in hepatitis C | Lee C | 2013.10.15 2013-A01 |
Drug Des, Dev. Ther. | ○ | GRRC, NRF |
||
| 3 | 3-aminopropyl functionalized magnesium phyllosilicate as an organoclay based drug carrier for improving the bioavailability of flurbiprofen. | Yang L, Cho SK, Shin HJ, Han HK |
2013.10.30 2013-B03 |
Int, J. Nanomedicine | ○ | NRF1, NRF2, GRRC |
||
| 4 | Pharmacokinetics of Isoliquiritigenin and ItsMetabolites in Rats: Low Bioavailability Is PrimarilyDue to the Hepatic and Intestinal Metabolism | Lee YK, Chin YW, Bae JK, Seo JS, Choi YH |
2013.11.25 2013-B03 |
Planta Med. | ○ | NRF, GRRC |
||
| 5 | Absorption, tissue distribution, tissue metabolism and safetyof a-mangostin in mangosteen extract using mouse models | Young Hee Choi, Seung Yon Han, You-Jin Kim, Young-Mi Kim, Young-Won Chin |
2014.01.25 2013-B03 |
Food Chem. Toxicol. | ○ | NRF, GRRC |
||
| 6 | Chemical genetics-based discovery of indole derivatives as HCV NS5B polymerase inhibitors | Guanghai Jin, Sungjin Lee, Moonju Choi, Seohyun Son, Geon-Woo Kim, Jong-Won Oh, Choongho Lee, Kyeong Lee |
2014.01.31 2013-A01 2013-B02 |
Eur. J. Med. Chem. |
○ | GRRC, NRF |
||
| 7 | Enhancement of Platelet Aggregation by Ursolic Acid and OleanolicAcid | Kim M, Han CH,Lee MY |
Accepted 2014.03.24 2013-B01 |
Biomol. Ther. | ○ | GRRC | ||
| 8 | 12-O-Tetradecanoylphorbol-13-Acetate Induces Keratin 8Phosphorylation and Reorganization via Expression of Transglutaminase-2 | Lee EJ, Park MK, Kim HJ, Kang JH, Kim YR, Kang GJ, Byun HJ, Lee CH |
2014.03.31 2013-B01 |
Biomol. Ther. | ○ | GRRC, Korea Healthcare Technology R&D project, MOHW |
||
| 9 | Involvement of Transglutaminase-2 in α-MSH-InducedMelanogenesis in SK-MEL-2 Human Melanoma Cells | Kim HJ, Lee HJ, Park MK, Gang J, Byun HJ, Par JH, Kim MK, Kim SY, Lee CH |
Accepted 2014.05.07 2013-B01 |
Biomol. Ther. | ○ | GRRC | ||
| 10 | Improved pH-dependent drug release and oral exposure of telmisartan, a poorly soluble drug through the formation of drug-aminoclay complex | Yang L, Shao Y, Han HK |
Accepted 2014.05.09 2013-B03 |
Int. J. Pharm. | ○ | NRF, MOHW, GRRC |
||
| 11 | Therapeutic Strategies for Metabolic Diseases: Small Molecule Diacylglycerol Acyltrasferase (DGAT) Inhibitors | Naik R, Obiang-Obounou BW, Kim M, Choi, Lee HS, Lee K |
Accepted 2014.05.14 2013-B02 |
Chem..Med.. Chem |
○ | GRRC, NRF |
||
| 12 | Korean Red Ginseng Extract Exhibits Neuroprotective Effects throughInhibition of Apoptotic Cell Death | Kim S, Lee Y, Cho J |
2014.06.01 2013-B01 |
Biol. Pharm. Bull. |
○ | GRRC, Korean Society of Ginseng |
||
| 13 | The Heterochromatin-1 Phosphorylation Contributes to TPA-induced AP-1 Expression | Choi WJ | Accepted 2014.05.26 2013-B02 |
Biomol. Ther. | ○ | GRRC, NRF |
||
| 14 | Mangosteen xanthones suppress hepatitis C virus genome replication | Choi M, Kim YM, Lee S, Chin YW, Lee C |
Accepted 2014.06.16 2013-A0 12013-B02 |
Biochem. Biophys. Res. Commun. |
○ | GRRC | ||
| 년 계 | 14 | |||||||
| 합 계 | 3 | 39 | ||||||
4차년도(2014.07.01~2015.06.30)
| 일련 번호 |
논문명 | 연구자 | 발표일과제번호 | 발표지 | 논문 수준 | 사사기관 | ||
|---|---|---|---|---|---|---|---|---|
| 국내 | 국외 | SCI | ||||||
| 1 | Molecular and chemical regulation of the keap1-nrf2 signaling pathway |
Keum YS, Choi BJ |
2014.07.10 2014-B02 |
Molecules | ○ | GRRC, KICOX |
||
| 2 | Pharmacokinetics, tissue distribution, and tentative metabolite identification of sauchinone in mice by microsampling and HPLCMS/MS methods | Kim YJ, Han SY, Seo JS, Chin YW, Choi YH |
2015.02.10 2014-B01 |
Biol. Pharm. Bull. |
○ | GRRC | ||
| 3 | Identification of a new selective chemical inhibitor of mutant isocitrate dehydrogenase-1 | Kim HJ, Choi BJi, Keum YS |
2015.03.31 2014-B02 |
J.Cancer Prevent. | 0 | GRRC | ||
| 4 | In vivo gastroprotective effect along with pharmacokinetics, tissue distribution and metabolism of isoliquiritigenin in mice | Choi YH, Kim YJ, Chae HS, Chin YW |
2015.04.15 2014-B01 |
Planta Med. | ○ | GRRC | ||
| 5 | Antiplatelet effect of a newly developed AMP-activated protein kinase activator YLF-466D | Liu Y, Park JM, Oh SJ, Chang KH, Lee MY |
2015.04.22 2014-B03 |
Eur. J.Pharmacol |
○ | GRRC | ||
| 6 | Neuroprotective and antioxidant effects of novel benzofuran-2-carboxamide derivatives |
Cho J, Park C, Lee Y, Kim S, Bose S, Choi M, Kumar AS, Jung JK, Lee H |
2015.05.01 2014-B01 |
Biomol& Ther. | ○ | GRRC NRF |
||
| 7 | Immortalization of primary keratinocytes and its application to skin research | Choi M, Lee C |
Accepted 2015.05.06 2014-A01 |
Biomol& Ther. | ○ | GRRC 보건산업진흥원 |
||
| 8 | Methods for treating interleukin-6 related diseases | Chin YW | Accepted 2015.05.22 2014-B03 |
Expert Opin.Ther.Pat | ○ | GRRC | ||
| 9 | Recombinant kinase production and fragment screening by NMR spectroscopy | Ahn HC, Han B |
Accepted 2015.04.27 2014-B02 |
Methods in Molecular biology | ○ | GRRC | ||
| 10 | Antimicrobial activity of doubly-stapled alanine/lysine-based helices | Dinh TTT, Kim DH, Luonga HX, Lee BJ, Kim YW |
Submitted 2015.04.30 2014-B02 |
Bioor. Med. Chem. Lett. | ○ | GRRC NRF |
||
| 11 | N-capping effect of stapled heptapeptides on antimicrobial activity | Dinh TTT, Kim DH, Nguyen TQ, Lee BJ, Kim YW |
Submitted 2015.05.28 2014-B02 |
Bull. Kor. Chem. Soc. | ○ | GRRC NRF |
||
| 12 | Novel lignans with IL-6 production inhibitory activity from larrea nitidia | Choi WJ | Submitted 2015.06.00 2014-A01 |
Bioor. Med. Chem. Lett. | ○ | GRRC, MEST | ||
| 년 계 | 1 | 11 | ||||||
5차년도(2015.07.01~2016.06.30)
| 일련 번호 |
논문명 | 연구자 | 발표일과제번호 | 발표지 | 논문 수준 | 사사기관 | ||
|---|---|---|---|---|---|---|---|---|
| 국내 | 국외 | SCI | ||||||
| 1 | Dose-Independent ADME Properties and Tentative Identification of Metabolites of α- Mangostin from Garcinia mangostana in Mice by Automated Microsampling and UPLC-MS/MS Methods |
Seung Yon Han, Byoung Hoon You, Yu Chul Kim,Young-Won Chin, Young Hee Choi | 15.06.20 2015-B01 |
PLOS ONE | O | GRRC NRF |
||
| 2 | α‑Mangostin Regulates Hepatic Steatosis and Obesity through SirT1-AMPK and PPARγ Pathways in High-Fat Diet-Induced Obese Mice | Young Hee Choi, Jin Kyung Bae, Hee-Sung Chae, Young-Mi Kim, Yim Sreymom, Ling Han, Ha Young Jang, Young-Won Chin |
15.11.15 2015-B03 |
J.Agric. Food Chem. |
O | GRRC NRF |
||
| 3 | Antioxidant and anti-inflammatory activities of N-((3,4-dihydro- 2H-benzo[h]chromene-2-yl)methyl)-4- methoxyaniline in LPS-induced BV2 microglial cells |
Moniruzzaman, Gyeongjun Lee, Shambhunath Bose,Minho Choi,Jae-Kyung Jung, Heesoon Lee,Jungsook Cho |
15.12.01 2015-B01 |
Biol. Pharm. Bull. | O | GRRC NRF |
||
| 4 | Antimicrobial and Hemolytic Activity of Stapled Heptapeptide Dimers | Young-Woo Kim Huy X. Luong, Do-Hee Kim, Bong-Jin Lee |
submitted yy.mm.dd 2015-B02 |
Bull. Kor. Chem. Soc. |
O | GRRC NRF |
||
| 5 | Identification of a resveratrol tetramer as a potent inhibitor of hepatitis C virus helicase | Lee S, Yoon KD, Lee M, Cho Y, Choi G, Jang H4, Kim B, Jung DH6, Oh JG, Kim GW, Oh JW, Jeong YJ, Kwon HJ, Bae SK, Min DH, Windisch MP, Heo TH, Lee C | 16.01.01 2015-A01 |
Br. J. Pharmacol. | O | GRRC NRF |
||
| 6 | Isoliquiritigenin ameliorates dextran sulfate sodium-induced colitis through the inhibition of MAPK pathway |
Young Hee Choi, Jin-Kyung Bae, Hee-Sung Chae, Young Ok Choi, Piseth Nhoek, Jong-Sun Choi, Young-Won Chin |
16.01.07 2015-B01 |
Int. Immunopharmacol. | O | GRRC KHIDI |
||
| 7 | The ethylacetate fraction from Physalis alkekengi inhibits LPS-induced pro-inflammatory mediators in BV2 cells and inflammatory pain in mice | Moniruzzaman, ShambhunathBose, Young-MiKim, Young-WonChin, Jungsook Cho |
16.04.02 2015-B01 |
J. Ethnopharmacol. |
O | GRRC | ||
| 8 | Mangosteen Extract Attenuates the Metabolic Disorders of High-Fat-Fed Mice by Activating AMPK |
Hee-Sung Chae, Young-Mi Kim, Jin-Kyung Bae, Sochivak Sorchhann, Sreymom Yim, Ling Han, Jin Hyub Paik, Young Hee Choi, Young-Won Chin |
16.02.01 2015-B01 2015–B03 |
J.MED. FOOD | O | GRRC NRF |
||
| 9 | Xanthones with pancreatic lipase inhibitory activity from the pericarps of Garcinia mangostana L. (Guttiferae) |
Hee-Sung Chae, Young-Mi Kim, Jin-Kyung Bae, Sochivak Sorchhann, Sreymom Yim, Ling Han, Jin Hyub Paik, Young Hee Choi, Young-Won Chin |
accepted 2015-B03 |
Eur. J.Lipid Science Technol. | O | GRRC NRF |
||
| 10 | Maackiapterocarpan B from Sophora tonkinensis Suppresses Inflammatory Mediators via Nuclear Factor-κB and Mitogen-Activated Protein Kinase Pathways |
Hee-Sung Chae, Hunseung Yoo, Young Hee Choi, Won Jun Choi, Young-Won Chin | 16.05.01 2015-A01 |
Biol. Pharm. Bull. | O | GRRC NRF NHIDI iPET |
||
| 11 | Crystal structures of apo- and AMP-bound human c-Jun N-terminal kinase3 | Yumi Eo, Byeong Gu Han, Myungbo Shim, Jong Soo Lim, Thuy Nguyen Thi Phuong, Phuong Pham Hoa, Hee Chul Ahn | Accepted 16.05.23 2015-B02 |
Bull.Kor. Chem.Soc. | O | GRRC NRF |
||
| 12 | Acetonitrile extract of Salvia miltiorrhiza Radix exhibits the growth-inhibitory effects on prostate cancer through the induction of cell-cycle arrest and apoptosis | June Lee, Bu-Young Choi, Young-Sam Keum | In press 16.03.01 2015-B02 |
Oncol. Lett. | 0 | GRRC | ||
| 13 | Treatment of α-mangostin Sensitizes 5-fluorouracil-resistant SNUC5 Colon Cancer Cells to Apoptosis | June Lee, Jong-Su Kang, Bu-Young Choi, Young-Sam Keum | In press 16.04.07 2015-B02 |
Biomol. Ther. | 0 | GRRC | ||
| 년 계 | 13 | |||||||
| 합 계 | 4 | 63 | ||||||
